| CITY | STATE | Miles | Time in Minutes | North/South Total Miles | Total Hours to Drive | Town Tidbits |
| Hurley | WI | 0 | 0 | 0 | 0 | Potato River Falls; Willy’s Still; IRON Horse Saloon; The Munch; Bear Chasers Lodge Bar and Grill |
| Mercer | WI | 22.8 | 25 | 25 | 0.42 | “Loon Capital of the World”. Mercer has the highest concentration of common loons in the world. |
| Manitowish Waters | WI | 10 | 12 | 12 | 0.62 | Little Bohemia (Dillenger/FBI shootout), 50+ miles of paved bike trails, North Lakeland Discovery Center |
| Woodruff/Minocqua | WI | 22 | 24 | 49 | 1.02 | Lumberjack show, Worlds Largest Penny and Home of the Min-Aqua-Bats, the oldest amateur ski show |
| Tomahawk | WI | 31.5 | 34 | 83 | 1.58 | Tomahawk on the Wisconsin River. |
| Merrill | WI | 23 | 25 | 108 | 2.00 | Home to Counsil Grounds State Park, Sawmill Brewing Co, Northwoods, Maple Farm, River Bend Trail |
| Wausau | WI | 19.4 | 23 | 131 | 2.38 | Rib Mtn State Park, Yawkey House Museum, Leigh Yawkey Woodson Art Museum, Granite Peak Ski Area |
| Mosinee | WI | 15.5 | 18 | 149 | 2.68 | Mosinee Brewing Company. Breweries. Mullins, River Park |
| Stevens Point | WI | 21 | 24 | 173 | 3.08 | University of Wisconsin–Stevens Point, Point Beer Brewery |
| Plainfield | WI | 25.9 | 27 | 200 | 3.53 | Hometown of Ed Gein, an American murderer known as “the Butcher of Plainfield” which inspired ‘Psycho’ |
| Hancock | WI | 7.8 | 10 | 210 | 3.70 | Greenwood State Wildlife Refuge with the Ice Age Trail system running through it. |
| Coloma | WI | 7.7 | 8 | 218 | 3.83 | Home to several recreational lakes, including Pleasant Lake, Wood Lake, and Mecan Lake, hike Ice Age Trail |
| Westfield | WI | 12 | 12 | 230 | 4.03 | Amish House Market, Beane’s Wood Lake Resort, and Pioneer Memorial Park |
| Portage | WI | 26.1 | 28 | 258 | 4.50 | Cascade Mtn Ski Area, Fort Winnebago, Wisc River, Surgeons Quarters, Indian Agency House, Portage Canal |
| Madison | WI | 38.4 | 49 | 307 | 5.32 | University of Wisconsin, Olbrich Botanical Gardens, annual Wisconsin Cheese Mart Festival |
| Stoughton | WI | 19.1 | 31 | 338 | 5.83 | Livsreise Norwegian Heritage Center and annual Syttende Mai celebration in May, Historic Opera House |
| Edgerton | WI | 13.5 | 19 | 357 | 6.15 | Rock River, Known locally as “Tobacco City U.S.A.” because of the importance of tobacco growing in the region |
| Janesville | WI | 11.7 | 18 | 375 | 6.45 | Lincoln-Tallman House, Rock County Historical Society, Rotary Botanical Gardens |
| Beloit/South Beloit | WI/IL | 13.1 | 25 | 400 | 6.87 | Beloit College, USA headquarters of eBates, Beckman Mill , DC Estate Winery |
| Roscoe | IL | 6.6 | 12 | 412 | 7.07 | Illinois Route 251 begins at the Wisconsin border, where it picks up the former alignment of U.S. Route 51 |
| Rockford | IL | 11.7 | 23 | 435 | 7.45 | City of Gardens, Anderson Japanese Gardens, Burpee Museum of Natural History, Rockford Art Museum |
| New Milford | IL | 7.9 | 18 | 453 | 7.75 | Kishwaukee River, Atwood Park |
| Holcomb | IL | 9.4 | 14 | 467 | 7.98 | Named for William H. Holcomb, General Manager of the Chicago and Iowa Railroad at the time |
| Rochelle | IL | 11.1 | 16 | 483 | 8.25 | Hub City, Rochelle Railroad Park at the intersection of the BNSF and Union Pacific Railroads |
| Mendota | IL | 28.6 | 35 | 518 | 8.83 | Mendota Lake Park. Union Depot Railroad Museum. Hume-Carnegie Museum |
| Peru | IL | 15.9 | 24 | 542 | 9.23 | Hegeler Carus Foundation, Matthiesson State Park, Westclox Museum, I&M Canal National Heritage Area |
| Tonica | IL | 9.2 | 14 | 556 | 9.47 | Old railroad town with population about 750 |
| Lostant | IL | 5.5 | 8 | 564 | 9.60 | Eat at The Lost-Ant Café |
| Wenona | IL | 7.3 | 10 | 574 | 9.77 | Old railroad town with population about 1000 |
| Rutland | IL | 12.6 | 16 | 590 | 10.03 | Little farm town of 259 people |
| Minonk | IL | 6.5 | 9 | 599 | 10.18 | Sutton’s Park, New Millenia Park |
| Panola | IL | 8.6 | 13 | 612 | 10.40 | Panola is one of the smallest communities in Illinois , Population 44 |
| El Paso | IL | 3.8 | 7 | 619 | 10.52 | South Point Park |
| Kappa | IL | 5.2 | 8 | 627 | 10.65 | Illinois 251 (Old 51) terminates at the intersection of I-39 and U.S. 51, located south of Kappa. |
| Hudson | IL | 5.5 | 8 | 635 | 10.78 | Evergreen Lake, Comlara Park |
| Normal/Bloomington | IL | 6.8 | 11 | 646 | 10.97 | Art Deco theatre, McLean Co Museum of History, Constitution Trail, Prairie Aviation Museum, Illinois State U |
| Randolph | IL | 10.7 | 18 | 664 | 11.27 | Mary’s River Covered Bridge, Fort de Chartres and Fort Kaskaskia and Pierre Menard State Historic Sites |
| Heyworth | IL | 5.1 | 8 | 672 | 11.40 | Eat at Hornet’s Nest or Prairie Fire Grill or Epiphany Farms Restaurant |
| Wapella | IL | 7.3 | 10 | 682 | 11.57 | Small Ag town population 513 |
| Clinton | IL | 5 | 7 | 689 | 11.68 | Clinton Nuclear Generating Station is located six miles away on Clinton Lake, Dewitt Co Museum |
| Maroa | IL | 8.6 | 12 | 701 | 11.88 | Full House Craft Beer & Gaming Lounge |
| Decatur | IL | 13.8 | 21 | 722 | 12.23 | Along the Sangamon River and Lake Decatur, Scovill Zoo, Decatur Park District |
| Elwin | IL | 4.8 | 7 | 729 | 12.35 | Population 119 |
| Macon | IL | 4.8 | 6 | 735 | 12.45 | Eat at Mattie’s or Whit’s End 51 , Population 1,130 |
| Moweaqua | IL | 6.7 | 9 | 744 | 12.60 | Pottawatamie word that means “she that weeps”, eat at Salty Farmer or Crazy Ladies Café |
| Assumption | IL | 8.3 | 11 | 755 | 12.78 | Assumption lays claim to the deepest coal mine (abandoned in the 1930s) in the state at over 1000′ |
| Dunkel | IL | 4.8 | 8 | 763 | 12.92 | Small unincorporated town, All that remains of Dunkel today are a few houses and a grain elevator |
| Pana | IL | 6.6 | 12 | 775 | 13.12 | City of Roses, Kitchell Park was added to the National Register of Historic Places in 1992 |
| Oconee | IL | 7.9 | 11 | 786 | 13.30 | Population 138 |
| Ramsey | IL | 10.6 | 13 | 799 | 13.52 | Population 895, eat at Boondocks |
| Vandalia | IL | 13.2 | 17 | 816 | 13.80 | Kaskaskia River, Vandalia Lake, Capital of Illinois when it became a state in 1818. |
| Vernon | IL | 11.6 | 13 | 829 | 14.02 | Population 103, eat at Joyce’s Café or Lazy Dog Restaurant & Bar |
| Patoka | IL | 3.3 | 5 | 834 | 14.10 | Population 525, eat at The Lucky Marble |
| Sandoval | IL | 10.1 | 12 | 846 | 14.30 | Population 1127, eat at Bub’s Pub |
| Centralia | IL | 6.6 | 9 | 855 | 14.45 | Raccoon Lake, Foundation Park, Lake Centralia, Crooked Creek Winery |
| Irvington | IL | 7.9 | 12 | 867 | 14.65 | Population 659, eat at Becker’s Snack Shack |
| Richview | IL | 4.7 | 7 | 874 | 14.77 | Population 232, small village |
| Ashley | IL | 4.3 | 8 | 882 | 14.90 | Population 462, eat at Lantern Pub Family Restaurant |
| Tamaroa | IL | 15.9 | 19 | 901 | 15.22 | Population 533, eat at the Black Sheep Saloon |
| Du Quoin | IL | 9.3 | 13 | 914 | 15.43 | Best known for hosting the annual DuQuoin State Fair and the Street Machine Nationals |
| De Soto | IL | 13.8 | 18 | 932 | 15.73 | Population 1381, named for Hernando de Soto, discoverer of the Mississippi River. Eat at Gressa’s Café |
| Carbondale | IL | 6.3 | 8 | 940 | 15.87 | Southern Illinois Univ, Several Festivals thoughout the year |
| Anna/Jonesboro | IL | 20.3 | 26 | 966 | 16.30 | Choate Mental Health and Development Center in Anna. Joneboro was site of a Lincoln-Douglas debate |
| Ullin | IL | 15.9 | 21 | 987 | 16.65 | Population 449, eat at Triple E Bar-B-Que |
| Pulaski | IL | 4.6 | 6 | 993 | 16.75 | Village of 235, named in honor of Polish Revolutionary War hero Casimir Pulaski. |
| Mounds | IL | 7.2 | 10 | 1003 | 16.92 | City of 616, eat at Drive Thru 51 or Huckleberry’s Pub |
| Cairo | IL | 8.3 | 11 | 1014 | 17.10 | Fort Defiance State Park, Mississippi-Ohio River Confluence, Cairo Custom House Museum, Magnolia Manor |
| Wickliffe | KY | 6.9 | 11 | 1025 | 17.28 | Wickliffe Mounds State Park and National Trail of Tears Site |
| Bardwell | KY | 8.6 | 11 | 1036 | 17.47 | Bardwell is a home rule-class city in and the county seat of Carlisle County, Magnolia Manor Museum |
| Clinton | KY | 14.9 | 18 | 1054 | 17.77 | Clinton is a home rule-class city and the county seat of Hickman County |
| Fulton/South Fulton | KY/TN | 14.4 | 21 | 1075 | 18.12 | Banana Capitol of the World, annual Banana Festival featuring the world’s largest banana pudding |
| Union City | TN | 11.9 | 18 | 1093 | 18.42 | Discovery Park of America which is a museum with many exhibits pertaining to local history |
| Troy | TN | 9.2 | 14 | 1107 | 18.65 | Full Throttle Sloonshine Distillery |
| Newbern | TN | 18.8 | 20 | 1127 | 18.98 | The Historic Depot downtown serves as a railroad museum and an Amtrak station, Depot Days Festival |
| Dyersburg | TN | 9.5 | 18 | 1145 | 19.28 | Forked Deer River, birthplace of the famous clown Emmett Kelly |
| Ripley | TN | 22.8 | 29 | 1174 | 19.77 | Lauderdale County Tomato Festival, Chickasaw National Wildlife Refuge, Tully State Forest, Ripley Park |
| Covington | TN | 15.1 | 20 | 1194 | 20.10 | Drive down the Main and Maple Streets of the South Main Historic District |
| Millington | TN | 21.9 | 32 | 1226 | 20.63 | Meeman-Shelby Forest State Park, Memphis International Raceway, and the USA Baseball Stadium |
| Memphis | TN | 16.9 | 27 | 1253 | 21.08 | “Home of the Blues” and “Birthplace of Rock ‘n’ Roll, Graceland, Hotel Peabody |
| Southaven | MS | 13.2 | 14 | 1267 | 21.32 | Tanger Outlets Southaven. Liberation Escape Rooms. Snowden Grove Park |
| Hernando | MS | 12.7 | 14 | 1281 | 21.55 | Recognized as a “Playful City USA” and is home to the award-winning Hernando Farmers Market |
| Senatobia | MS | 16.5 | 20 | 1301 | 21.88 | Senatobia was originally a rest stop on the trail leading to Hot Springs, Ark |
| Batesville | MS | 24.2 | 25 | 1326 | 22.30 | Batesville Mounds, a designated Mississippi Landmark and a destination on the Mississippi Mound Trail, |
| Grenada | MS | 40.7 | 39 | 1365 | 22.95 | Grenada’s Downtown Historic District, nestled in the curve of the Yalobusha River |
| Winona | MS | 26.5 | 29 | 1394 | 23.43 | Christ’s Cross at the Crossroads 120′ Tall |
| Durant | MS | 31.1 | 40 | 1434 | 24.10 | Founded in 1858 as a station on the Mississippi Central Railroad, later part of the Illinois Central |
| Canton | MS | 34.4 | 41 | 1475 | 24.78 | Birthplace of the Mississippi Art Colony, Movie Capital of MS |
| Jackson | MS | 25.8 | 27 | 1502 | 25.23 | “The City with Soul”, 29 museums spread out around the city, three cultural and historic districts to explore |
| Crystal Springs | MS | 25.5 | 29 | 1531 | 25.72 | Crystal Springs, Tomato Festival, Concerts in the Park |
| Hazelhurst | MS | 9.9 | 17 | 1548 | 26.00 | The annual Robert Johnson Blues and Heritage Festival |
| Beauregard/Wesson | MS | 10.7 | 14 | 1562 | 26.23 | Wesson Attendance Center and Copiah-Lincoln Community College. Historical Cotton Center |
| Brookhaven | MS | 11.3 | 20 | 1582 | 26.57 | Lincoln County Historical and Genealogical Society Museum and Military Memorial Museum |
| McComb | MS | 26.6 | 33 | 1615 | 27.12 | McComb Railroad Museum and Percy Quinn State Park |
| Magnolia | MS | 9.8 | 16 | 1631 | 27.38 | City of Magnolia’s Annual Mardi Gras Ball |
| Kentwood | LA | 17 | 18 | 1649 | 27.68 | Kentwood Historical and Cultural Arts Museum-honors local WWII veterans, Britney Spears hometown |
| Amite City | LA | 14.8 | 23 | 1672 | 28.07 | Major oyster processing center and home of the Oyster Festival. |
| Independence | LA | 6.5 | 11 | 1683 | 28.25 | “Little Italy” hosts the Sicilian Heritage Festival, Home to Amato’s, a Louisiana Native Winery |
| Hammond | LA | 10.8 | 19 | 1702 | 28.57 | Southeastern Railroad Museum |
| Ponchatoula | LA | 5.7 | 12 | 1714 | 28.77 | Ponchatoula Strawberry Festival held annually in April and is one of the biggest festivals in the region. |
| Laplace | LA | 28.3 | 28 | 1742 | 29.23 | “Andouille Capital of the World,” the annual Andouille Festival held each October at the Hwy 51 Park |